Dihexa
An experimental hepatocyte growth factor mimetic discussed for synaptic repair—high hype, thin human evidence.
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✨ real molecule sketch
On your supplement label?
Dihexa
Wellness products may list collagen hydrolysates, copper peptides, or research compound names— we decode the jargon.
Structure (cute edition)
✨ real molecule sketch
This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.
INCI: Dihexa · ~4 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: chemical compound — Wikipedia
PubMed: 17 indexed papers (search PubMed)
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
- Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats. · Journal of Huntington's disease
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy. · Stem cell research & therapy
- AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway. · Brain sciences
- Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies. · Annals of medicine and surgery (2012)
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies. · Neuroscience and biobehavioral reviews
- Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells. · Current protocols in stem cell biology
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure. · Frontiers in cellular neuroscience
ChEMBL: CHEMBL2203985
What brands say it does
Dihexa was reported in animal studies to potently promote synaptic connectivity—far stronger than BDNF in some lab models. Human cognitive trials are essentially absent. Sold as a research compound online; oral bioavailability and long-term safety are unknown.
Where you’ll find it
Nootropic forums, research-chemical vendors, and podcast mentions—not pharmacies or mainstream supplements.
Other names you might see
PNB-0408
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
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Educational only—not medical advice. Not prescribing or dosing guidance. Talk to your doctor before starting any peptide protocol.